100 Bizarre Potions With Side Effects So Crazy They Might Just Ruin DND Forever

In the whimsical world of tabletop RPGs, where the line between reality and fantasy blurs like a Van Gogh painting in a rainstorm, potions are the spice of life—or, at the very least, the spice of your campaign. Within this enchanting chaos, every sip is a gamble, every vial a Pandora’s Box of possibilities. These concoctions, brewed with dubious diligence by eccentric alchemists or hapless adventurers, promise to add layers of intrigue and unpredictability to your adventures. Whether your party stumbles upon an alchemist’s shop with a penchant for the peculiar or attempts to whip up their own brews, these potions ensure that monotony is banished from the realm.

Imagine a world where creativity flows as abundantly as the magical ingredients that clutter a sorcerer’s pantry, where a potion’s effect can range from the hilariously unexpected to the dangerously transformative. In these lands, a single vial can turn a stoic barbarian into a giggling mess or change a quiet monk into the life of the party—literally. Potions become plot devices, comical mishaps, or the unexpected edge needed to triumph over insurmountable odds. The unpredictability they inject makes each campaign as unique as the fingerprints on a potion bottle.

The allure of potion experimentation is irresistible. Adventurers never quite know if they’re drinking liquid luck or bottled chaos, which is precisely what makes introducing these potions into your campaign so enticing. Expect everything from a hero gaining ten temporary toes to a villain spontaneously learning how to sing opera in flawless Elvish. The potential for mishaps and miracles is matched only by the players’ ingenuity in leveraging—or surviving—them.

As you enter this realm of potion-induced pandemonium, prepare for enchantment, excitement, and escapades that defy explanation. Whether your goal is laughter, triumph, or simply the unexpected, these brews have got you covered. Welcome to the saga of 100 experimental potions and their wild side effects—a magical journey awaits.

How to Use These Potion Tables

In the magical mayhem of tabletop RPGs, the potion tables presented here are your secret weapon for adding whimsy and chaos to any session. Each potion’s effect is described with just enough flair to inspire giggles or gasps, as they combine whimsy with fantastical twists. Game Masters (GMs) can use these d20 potion tables to insert specific potions into their campaign’s narrative tapestry or simply roll on the complete d100 list for a surprising twist that could redefine the party’s trajectory.

The beauty of these potions lies in their versatility—they can serve as quirky plot devices, game-changing boons, or delightful mischief-makers in the hands of your players. Whether an adventurer seeks a planned advantage or a serendipitous surprise, these potions offer endless opportunities for storytelling and player engagement. Think of them as the salt and pepper of your fantasy feast—adding flavor, spice, and the occasional amusing cough.

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For GMs, employing these potions as narrative tools becomes a playful art form. Perhaps a potion is gifted by a wise old wizard with a twinkle in his eye—or maybe it’s stumbled upon in the dusty recess of a dragon’s hoard. Regardless of their introduction, the chaos and creativity unleashed can provide as much entertainment for the GM as it does for the players. It’s a recipe for adventure, laughter, and a shared sense of wonder.

In a medieval-style laboratory, an alchemist holds a vial of bizarre potions, the image pixelated and glitching. Shelves lined with bottles and a DND spellbook peek from the shadows as light filters through arched windows, casting an aura thats mysterious and magical.

d20 Potions for Everyday Heroics (1 – 20)

Amidst the daily grind of dungeon delving and dragon slaying, sometimes an adventurer just needs a little pick-me-up—or, maybe, a pick-me-bizarre. Welcome to the quirky world of everyday heroics, where these potions offer a touch of whimsy to lighten the load of mundane predicaments. From granting temporary telepathy to turning one’s skin a vibrant shade of blue, these brews ensure that even the most routine quests are spiced up with unexpected flair.

d20Potion Effect Descriptiond100
1Grants temporary telepathy, but only with cats. Enjoy deciphering feline secrets, mostly about naps and disdain for non-cat creatures.1
2Turns the drinker’s skin a vibrant shade of blue, making them look like an overgrown Smurf.2
3Bestows the ability to understand and speak in rhyme; useful for poetry slams, less so in tactical negotiations.3
4Gives the user the irresistible urge to dance, regardless of the situation. Watch out for impromptu waltzes mid-battle!4
5Allows the drinker to see through walls, but only in black-and-white like an old detective movie.5
6Blesses the user with a melodious singing voice, but only when they sing about cheese.6
7Causes potted plants nearby to applaud whenever you make a grand statement.7
8Infuses the user with unmatched confidence and the belief that they are the chosen one… in amateur theatre.8
9Creates an invisible but annoying pixie companion that only the drinker can see or hear, constantly offering unsolicited advice.9
10Gives the ability to snap fingers and produce a harmless spark of light, perfect for dramatic reveals at parties.10
11Temporarily swaps the drinker’s voice with that of a talking parrot. Unnerving for them, amusing for everyone else.11
12Makes the user smell like freshly baked bread to anyone within five feet—beware of hungry followers.12
13Allows the user to float two inches off the ground, but only moves at a snail’s pace.13
14Enables the drinker to communicate with insects; sadly, most bugs just want to talk about dirt and leaves.14
15Grants the ability to find lost keys with uncanny accuracy. If only it worked for lost sanity.15
16Turns the drinker’s hair into snakes, much like Medusa, but they’re friendly and rather chatty.16
17Causes the user to glow in the dark like a neon sign, handy for clubbing, less so for stealth missions.17
18Endows the consumer with a photographic memory for awkward social encounters.18
19Temporarily changes the drinker’s tongue to the delectable flavor of chocolate. Try not to bite it.19
20Causes an aura of calm, making the user irresistible to puppies and kittens.20

These potions are perfect for injecting humor or minor inconveniences into your campaign, sparking moments that players will recount for sessions to come. With effects that range from the mildly amusing to the subtly transformative, each sip is a chance to break the ice of seriousness and invite a wave of laughter into the adventure.

A hooded figure in an abstract, paint-like style clutches a bizarre potion bottle in one hand, question marks swirling around their head. The body dissolves like side effects into paint splashes, merging with the beige background.

d20 Potions for the Brave and Foolhardy (21 – 40)

In the daring dance of destiny, some adventurers crave a bit more risk—a gamble with greater stakes. Enter the potions for the brave and foolhardy, concoctions that balance on the precipice of boon and bane. These effects might amplify a warrior’s strength at the cost of uncontrollable sneezing or grant an adventurer wings… with a tendency for inverted flight. Ideal for thrill-seekers, these potions test the mettle of those who dare to dream dangerously.

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d20Potion Effect Descriptiond100
1Amplifies strength tenfold, but induces sneezing fits that launch nearby objects like projectiles.21
2Gives the drinker wings for flight, but they struggle to fly right-side up.22
3Bestows the power of invisibility, but only while standing completely still.23
4Triples jumping ability, but every leap triggers a chorus of quacking ducks.24
5Grants the ability to breathe underwater, but only when holding one’s breath.25
6Transforms the user into a giant, but their voice comes out in a high-pitched squeak.26
7Temporarily allows mind reading, but only the drinker’s own thoughts.27
8Creates a protective shield of bubbles that giggle when popped.28
9Causes temporary animal transformation, turning the drinker into a majestic unicorn with a taste for carrots.29
10Provides night vision that’s as good as an owl’s. Unfortunately, daylight becomes overwhelmingly bright.30
11Changes skin texture to that of smooth marble, making the drinker oddly reflective in the sun.31
12Empowers with super speed, but running produces cartoonish sound effects.32
13Allows the drinker to converse with trees, though most are found to be incredibly dull.33
14Temporarily transforms laughter into actual fire-breathing. Use jokes with caution.34
15Infuses with the ability to mimic any voice but requires a loud hiccup beforehand.35
16Envelops the user in an aura of courage, and an inexplicable urge to challenge every squirrel to a duel.36
17Heightens senses to an extreme, causing even the faintest whisper to sound like a thunderclap.37
18Alters body temperature control, making anything touched feel hot or cold to others, but not to the drinker.38
19Gives the ability to phase through walls, but leaves clothing and gear on the other side.39
20Causes limbs to stretch like rubber but makes the drinker prone to unintentional slapstick feats.40

These potions encourage GMs to challenge players’ problem-solving skills or introduce unexpected twists during critical campaign moments. Each quaffed concoction presents a thrilling opportunity—or a comedic crisis—prompting creative thinking and daring deeds.

A fantasy illustration of an elf with flowing hair looking up in surprise, clutching a bottle labeled Bizarre Potions. The scene is in black and white, emphasizing intricate details and expressive features, reminiscent of a mysterious DND quest.

d20 Potions for Mystical Transformations (41 – 60)

Ah, the allure of transformation, where potions provide metamorphic magic in a bottle. These potions offer enchanting experiences, from moments of temporary invisibility to transforming an adventurer into a more talkative squirrel. They embody the unpredictable nature of magic, inviting players to embrace change and explore new facets of their characters, while testing their adaptability to the fantastical.

d20Potion Effect Descriptiond100
1Turns the user invisible, but creates a sound like wind chimes whenever they move.41
2Transforms the drinker into a squirrel, who can speak impeccably well on topics of acorns and bushy tails.42
3Changes appearance to resemble the last person spoken to, but with a mischievous twinkle in their eye.43
4Allows one to walk on ceilings and walls like a fly, but makes hands sticky to everything else.44
5Momentarily transforms the user into a statue that can only blink and nod.45
6Gives the drinker gills and fish scales, essential for winning over any aquarium.46
7Provides the body of a centaur, but with a preference for galloping into coffee tables.47
8Turns teeth into glowing gemstones that reflect the user’s mood.48
9Causes hair to grow rapidly and animate like a friendly sea anemone.49
10Reshapes the drinker into a mirror image of their pet, complete with behavior mimicry.50
11Changes eyes to kaleidoscopes, offering beautiful but distracting visions.51
12Allows the ability to exude a calming pheromone that soothes nearby creatures—mostly turtles.52
13Morphs one leg into a pogo stick, leading to unintended bouncy adventures.53
14Turns skin to a reflective silver, causing curious bystanders to gawk.54
15Temporarily grants a fiery mane of hair, both in appearance and temperament.55
16Alters perception, so the drinker sees everyone in slow motion, complete with dramatic soundtrack.56
17Changes hands into lobster claws, surprisingly functional for sand sculpting.57
18Provides the ability to speak any language, accompanied by an irresistible urge to narrate everything.58
19Converts feet to suction cups, handy for scaling smooth surfaces with ease.59
20Grants the ability to shape-shift at will, but only into small woodland creatures.60

These potions are perfect for adding depth to character development or setting the stage for role-playing challenges. As roles change and personalities morph, the potential for new narratives unfurls—making the adventure as malleable as the reality within it.

A surprised elf with long, swirling hair and pointed ears holds a bizarre potion bottle that drips ominously. Dressed in a detailed, medieval-style outfit with a cloak, the scene captures the essence of DND magic in sepia tones, hinting at unforeseen side effects.

d20 Potions with Elemental Flare (61 – 80)

Harness the raw power of elements with potions infused with solar flare and zephyr whispers. From fire-breathing elixirs to aqueous concoctions for water-walking, these transformative brews augment elemental encounters—adding wild excitement to any adventurer’s repertoire. The elements are your playground, and a sip is a ticket to mastery over nature’s chaos.

d20Potion Effect Descriptiond100
1Enables the user to breathe fire, though hiccups may backfire spectacularly.61
2Allows walking on water, but leaves dry patches of aquatic life clinging to boots.62
3Turns the drinker’s touch into a flash-freeze effect, handy for impromptu ice sculptures.63
4Temporarily grants the user the ability to control gusts of wind at sneeze-induced force.64
5Causes the drinker to burst into harmless flames whenever they laugh heartily.65
6Transforms the user’s fists into rocky boulders, perfect for rock-paper-scissors.66
7Allows temporary flight on wings made from swirling mist, prone to dispersing with loud sounds.67
8Causes water to ripple and move aside with a wave of the hand, tailors favorite.68
9Allows user to absorb electricity, which makes hair stand on end until discharged.69
10Infuses the user with the power of molten magma, though requires a heatproof outfit.70
11Allows the control of plants, especially delightful for impressing flora aficionados.71
12Turns the user into a human lightning rod, attracting curious weather phenomena.72
13Grants the ability to dance upon air currents, only when the user hums a jaunty tune.73
14Converts the user’s breath to fog, perfect for dramatic entrances, less so for clear communication.74
15Empowers the user to move stones telekinetically, but they must be sung to first.75
16Causes skin to shimmer with a sandy texture, dramatically dispersing with a snap of fingers.76
17Bestows the ability to create minor earthquakes with a well-placed stomp.77
18Temporarily turns the user into a living cloud, with a penchant for floating over crowds.78
19Provides a fiery but transient aura, igniting nearby candles and torches with flamboyant flair.79
20Allows the drinker to clap and summon a rainstorm local only to themselves.80

These potions enhance the thematic experience of elemental dungeons or act as wildcards during elemental skirmishes. Their effects can lead a campaign into unexpected territory, where nature’s fury or favor dictates the narrative.

A surprised elf with large ears and a medieval outfit stands in a DND potion shop, holding a small vial. Her long hair swirls into a vortex above her head. Shelves filled with bizarre potions line the walls, each promising enchanting adventures or unexpected side effects.

d20 Potions for Social Scenarios (81 – 100)

Potions aren’t just for battles and high-stakes quests; they can be the life—or the ruiner—of a party. In the realm of social scenarios, these potions influence interactions, some making the user unbearably charming (or obnoxiously so), while others cause everyone to hear them in verse. Perfect for spicing up negotiations or gatherings, these brews add unexpected dynamics to social circles.

d20Potion Effect Descriptiond100
1Makes the drinker irresistibly charming, but only to livestock and certain ferns.81
2Causes the user to speak only in rhyme, leading to unintended slapstick conversations.82
3Allows the user to convince others of anything, as long as it’s utterly implausible.83
4Empowers the voice with a resonant echo, perfect for dramatic declarations.84
5Gives the ability to mimic any persona, but only when wearing a comically oversized hat.85
6Turns all spoken words into sound effects from a busy marketplace.86
7Causes anyone the drinker speaks to, to suddenly misunderstand directions—left is right, up is down.87
8Bestows the power of persuasion, but only when discussing the merits of eggplants.88
9Turns the drinker’s voice into a sweet serenade, making them irresistible karaoke partners.89
10Causes nearby creatures to hear the drinker’s words as soothing lullabies.90
11Grants a magnetic personality, literally attracting small metallic objects like spoons and coins.91
12Makes the user speak in a language only understood by household pets—they’re surprisingly opinionated.92
13Infuses the drinker with eloquent speech, but only when reciting grocery lists.93
14Causes the drinker’s laughter to sound like a cacophony of clucking chickens.94
15Temporarily allows the user to mind-meld with pastries, knowing their secrets.95
16Enhances the ability to win debates, but only on the topic of favorite cloud shapes.96
17Grants a persuasive aura, causing anyone nearby to feel compelled to offer snacks without reason.97
18Causes everything the drinker says to sound like a dramatic monologue.98
19Allows for perfect pronunciation of any word, in any language, aside from their own name.99
20Causes the user to become the life of any party, though they can only speak in puns.100

These potions are ideal for fostering roleplay opportunities, creating humorous misunderstandings, or setting the scene for social intrigue. They bring fun, antics, and often a bit of pandemonium to the table.

Final Thoughts on Experimental Potions

Experimental potions offer far more than mere magical effects—they are storytelling catalysts that evoke surprise, humor, and strategic creativity. Each potion is an invitation to explore the unknown, to dive headlong into a narrative bubbling with potential. A single dose can spiral into tales of misadventure, providing a fortuitous edge or a challenge to overcome, resulting in unforgettable party moments.

In the hands of a creative GM, potions can transform the mundane into the magnificent. They can be used to spark entire story arcs or to weave new threads into existing narratives. The randomness of a potion’s effect mimics life itself; just when you think you know what’s coming, a potion throws you a curveball—sometimes literal, sometimes metaphorical.

Players are encouraged to embrace the unknown, to take a gulp and see where it leads. These magical concoctions are keys to unlocking potential hidden in characters and campaigns, a reminder that adventure is not just about combat or treasure, but the stories that unfold along the way. Their allure lies in the unexpected, in the laughter and surprise they bring.

For those who find joy in the unpredictable, potions offer a playground of possibilities. They invite players and GMs alike to take risks, to laugh in the face of the unexpected, and to create legends that will be told for many sessions to come. So, here’s to the experimental potions and the wild, wonderful worlds they create.

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Whether used as a narrative device or an amusing sidetrack, potions bring enchantment, laughter, and unforgettable scenarios to any campaign. They are a reminder that in the magical world of RPGs, anything is possible—and that’s precisely why we play.

Heidi Jiang

LitRPG Author Heidi Jiang

A native Hoosier her whole life, Heidi Jiang discovered her love of gaming at an early age. She’s a big fan of the Super Mario series ... and any book with a mushroom on the cover. In all seriousness, she loves reading and playing just about anything when she finds the time. I am Spartacus! I am a wage slave! I am Paul Bellow! She currently resides in Indiana with her husband, a dog named Lucky, a cat named Oliver, and a couple children rapidly heading toward being teens. Over the years, Heidi Jiang has been a book reviewer, freelance copy editor, editor at a small publishing company, and executive editor at her school’s literary magazine.